Dynamic Contrast-Enhanced Ultrasound Enhances Microvascular Perfusion Deficit Detection

imagingBiz | Microvascular perfusion deficits and reduced arterial perfusion reserve are clearly detectable in patients with peripheral arterial disease (PAD) when dynamic contrast-enhanced ultrasound (CEUS) is used after transient arterial occlusion, report the authors of a feasibility study published online and in the August issue of Investigative Radiology.

The study involved 20 patients with PAD, Rutherford classification grade I, category III, and 20 healthy volunteers. Low-mechanical index CEUS (7 MHz; MI, 0.28) was performed to the dominant lower leg after start of a continuous automatic intravenous injection of 4.8 mL suspension with micro-bubbles containing sulfur hexafluoride. Perfusion of the calf muscle was monitored by CEUS before, during, and after release of arterial occlusion at the thigh level lasting for 60 seconds.

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